CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

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CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A) Left: Mass cytometry analysis of CD45RA and CLA expression by live gated CD3+CD45+ PBMCs showing the gate used to define CD3+CLA+ T cells for subsequent clustering analysis. Right: t-SNE analysis and clustering of CD3+CLA+ T cells from blood of five healthy donors based on the expression of CD4, CD8, CCR7, CD103, β7 integrin, CXCR3, CCR6, CCR4, CCR10, Foxp3, CD27, CD25, CD161, and CD56. (B) Heat map showing relative expression of the indicated markers in each of the CD3+CLA+ cell clusters. (C) t-SNE analysis of CD3+CLA+ T cells overlaid with relative expression of the indicated markers. Maria M. Klicznik et al. Sci. Immunol. 2019;4:eaav8995 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works