Schematic representation of the putative mechanism of P450 aromatase activation induced by d-Asp in frog neurons. d-Asp is recognised by the receptor for.

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Schematic representation of the putative mechanism of P450 aromatase activation induced by d-Asp in frog neurons. d-Asp is recognised by the receptor for N-methyl-d-aspartic acid (NMDA-R), whose activation increases cAMP. Schematic representation of the putative mechanism of P450 aromatase activation induced by d-Asp in frog neurons. d-Asp is recognised by the receptor for N-methyl-d-aspartic acid (NMDA-R), whose activation increases cAMP. The resulting augmentation of cAMP concentration could then activate a variety of protein kinases (PKA), resulting in the phosphorylation of the CREB protein (P-CREB) to transform it into a transcriptional regulator, which would then lead to an increase in P450 aromatase synthesis. This enzyme induces 17β-estradiol (E2) production from testosterone (T), with a consequent increase of its receptor (ERα). Lavinia Burrone et al. J Exp Biol 2012;215:3559-3565 © 2012.