MK-8628 modulates transcriptional signatures of activated T lymphocytes. MK-8628 modulates transcriptional signatures of activated T lymphocytes. Gene.

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MK-8628 modulates transcriptional signatures of activated T lymphocytes. MK-8628 modulates transcriptional signatures of activated T lymphocytes. Gene expression profiles of T lymphocytes isolated from healthy human donors and stimulated with anti-CD3/CD28 mAbs in the presence or absence of 200 nM MK-8628 for 24 h. (A and B) Volcano plots of differential gene expression of stimulated CD4+ (A) or CD8+ (B) T lymphocytes treated with MK-8628 versus untreated controls. Shown are the 123 genes preselected for Fluidigm analysis pooled across all experiments. (C) Shown in the heatmap are the absolute gene expression values of the 123 genes, where each horizontal line represents an individual donor. The color gradient represents center scaled Log2 expression values (−2.5 to 2.5). Data are from three independent experiments with four donors per experiment. Peter Georgiev et al. ImmunoHorizons 2019;3:294-305 Copyright © 2019 The Authors