The natural history of IgE-mediated cow's milk allergy

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Presentation transcript:

The natural history of IgE-mediated cow's milk allergy Justin M. Skripak, MD, Elizabeth C. Matsui, MD, MHS, Kim Mudd, RN, Robert A. Wood, MD Journal of Allergy and Clinical Immunology Volume 120, Issue 5, Pages 1172-1177 (November 2007) DOI: 10.1016/j.jaci.2007.08.023 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 CMA resolution over time. Kaplan-Meier survival curves for development of tolerance to cow's milk over time using 3 definitions for tolerance. The black line is the survival curve for criteria 1, the red line is the survival curve for criteria 2, and the blue line is the survival curve for criteria 3. Journal of Allergy and Clinical Immunology 2007 120, 1172-1177DOI: (10.1016/j.jaci.2007.08.023) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Trend in cm-IgE levels over time by final CMA status. Scatter plots of all cm-IgE levels recorded, by age, to age 18 years (n = 2498). A, All values in the group with persistent CMA (n = 1651). B, All values in the group with resolved CMA (n = 847). Nonparametric smoothed curves show the trend in cm-IgE levels over time. These curves approximate the mean value at any given age. Journal of Allergy and Clinical Immunology 2007 120, 1172-1177DOI: (10.1016/j.jaci.2007.08.023) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Relationship of peak cm-IgE level to resolution of IgE-mediated CMA over the period of the first 18 years of life. Patients were stratified by peak cm-IgE level, and survival curves for each stratum of peak cm-IgE level were plotted. The number of patients in each stratum was as follows: <2 kU/L (n = 162); 2-4.9 (n = 106); 5-9.9 (n = 85); 10-19.9 (n = 115); 20-49.9 (n = 107); 50+ (n = 229). Journal of Allergy and Clinical Immunology 2007 120, 1172-1177DOI: (10.1016/j.jaci.2007.08.023) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions