The Potential for Muscarinic Receptor Subtype-Specific Pharmacotherapy for Alzheimer's Disease  MICHAEL McKINNEY, Ph.D.  Mayo Clinic Proceedings  Volume 66, Issue 12, Pages 1225-1237 (December 1991) DOI: 10.1016/S0025-6196(12)62474-4 Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Diagram of some major central cholinergic pathways involved in cortical and hippocampal function in the human brain. Curved arrows indicate only basic aspects of connectivity and do not show actual fiber pathways. DB = diagonal band of Broca; LDT = lateral dorsal tegmental nucleus (and associated pedunculopontine nucleus); MS = medial septum; nBM = nucleus basalis of Meynert. Mayo Clinic Proceedings 1991 66, 1225-1237DOI: (10.1016/S0025-6196(12)62474-4) Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Diagram of some fundamental structural features of muscarinic receptors. Numbered cylinders indicate transmembrane α-helical domains of receptor. Heavy line segments are regions in which amino acid sequences are unique for each subtype. COOH = carboxyl-terminal; H2N = amino-terminal. Mayo Clinic Proceedings 1991 66, 1225-1237DOI: (10.1016/S0025-6196(12)62474-4) Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions