E11 pancreas cultured for 6 days in the presence of morpholine-ring antisense against GIP, GIPR, or control. E11 pancreas cultured for 6 days in the presence.

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E11 pancreas cultured for 6 days in the presence of morpholine-ring antisense against GIP, GIPR, or control. E11 pancreas cultured for 6 days in the presence of morpholine-ring antisense against GIP, GIPR, or control. Immunohistochemistry was performed for insulin and Pdx-1 (A, B, and C), Nkx2.2 and caspase (D, E, and F), BrdU (G, H, and I), and sox9 (J, K, and L). Both ligand and receptor antisense treatment significantly affected endocrine differentiation, as shown by decreased insulin and Nkx2.2 staining (B, C, E, and F). We also saw a decrease in an undifferentiated progenitor cell population suggested by decreased Pdx-1 and sox9 staining. However, the antisense treatment did not induce apoptosis (D, E, and F) or change the proliferation rate (G, H, and I) (magnification size bars: 20 μmol/L). (A high-quality digital representation of this figure is available in the online issue.)‏ Krishna Prasadan et al. Diabetes 2011;60:548-554 ©2011 by American Diabetes Association