Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with.

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Presentation transcript:

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome Nathalie Neveu, M.D., Louis Granger, M.D., Pierre St-Michel, M.D., Hélène B. Lavoie, M.D. Fertility and Sterility Volume 87, Issue 1, Pages 113-120 (January 2007) DOI: 10.1016/j.fertnstert.2006.05.069 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Ovulation, pregnancy, and spontaneous abortion rates (sab) for patients taking CC (gray), metformin (black), or combination (white). Ovulation rate of patients taking metformin was significantly better than that of patients taking CC (*P=.005). Pregnancy and spontaneous abortion rates were equivalent in the three groups. Neveu. Metformin and clomiphene citrate in PCOS women. Fertil Steril 2007. Fertility and Sterility 2007 87, 113-120DOI: (10.1016/j.fertnstert.2006.05.069) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Time to conception for patients taking CC (gray), metformin (black), or combination (white). Most patients taking CC conceived within first 6 months of therapy. Patients taking metformin alone or in combination conceived throughout first year of treatment. Some patients required over a year to conceive. Neveu. Metformin and clomiphene citrate in PCOS women. Fertil Steril 2007. Fertility and Sterility 2007 87, 113-120DOI: (10.1016/j.fertnstert.2006.05.069) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions