PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PKIs block DHT + bombesin-induced transactivation.

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PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PC-3 cells were treated as indicated in Fig. 1<$REFLINK> legend and incubated with medium containing the following: column pair 1, medium only (Control); column pair 2, 10 pm DHT (DHT); column pair 3, 5 nm bombesin (Bomb); column pair 4, DHT + bombesin (DHT+Bomb); column pair 5, 10 μm PKI (PKI); column pair 6, 10 μm MAP kinase inhibitor PD 98059 (PD 98059); column pair 7, 10 μm protein kinase C inhibitor GF-109203X (GF-109203X); column pair 8, DHT + bombesin + PKI (DHT +Bomb+PKI); column pair 9, DHT + bombesin + PD 98059 (DHT+Bomb+PD); column pair 10, DHT + bombesin + GF-109203X (DHT+Bomb+GF); column pair 11, DHT + bombesin + protein kinase inhibitors mixture (DHT+Bomb+Mix). Cells were pretreated for 1 h with inhibitors and then incubated in medium containing bombesin and DHT for 24 h, and luciferase activities were measured. Results are expressed as the relative percentage of activity, with the values resulting from DHT + bombesin set to 100%. Mean values were calculated from three independent experiments performed in duplicate; bars, SE. Jie Dai et al. Clin Cancer Res 2002;8:2399-2405 ©2002 by American Association for Cancer Research