UNIVERSITY OF COIMBRA Faculty of Science and Thecnology

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UNIVERSITY OF COIMBRA Faculty of Science and Thecnology Department of Chemistry Dealing with the (ab)use of antibiotics: hybrid materials for heterogeneous catalytic downstream treatment Giusi Piccirillo (PhD student) Supervisors: Prof. Mário José Ferreira Calvete Prof. Maria Ermelinda da Silva Eusébio Prof. João Paulo C. Tomé Lisbon, July 2019

What is the CQC? Unit dedicated to research in Chemistry in the University of Coimbra Research infrastructure of the Department of Chemistry of the University of Coimbra Involves about 90 integrated scientists with PhD degree, plus many Doctoral, Masters and project students

Developing collaborations with industry Main objectives: Advancing research Industry University Developing collaborations with industry Providing high-level advanced training to national and international students

What is the real problem? Fig.1 Global increase and geographic convergence in antibiotic consumption between 2000 and 2015, published March 26, 2018 in the Proceedings of the National Academy of Science (PNAS). Pharmaceuticals in drinking-water, WHO report, 2012. Available at www.who.int ISBN 978-92-4-150208-5. http://apps.who.int/iris/bitstream/10665/44630/1/9789241502085_eng.pdf accessed on 25-03-2017. E. Y. Klein, T. P. Van Boeckel, E. M. Martinez, S. Pant, S. Grandra, S. A. Levin, H. Goossens, R. Laxminarayan, PNAS, 2018. G.Gopalakrishna, J. Knoeff, M. Verhoef, T. Prasad, Antimicrobial Resistance Benchmark 2018 Methodology Report, 2017.

How to solve this problem… Direct sunlight Homogeneous Processes Heterogeneous Processes O. Gonzalez, C. Sans, S. Esplugas, J. Hazard Mater., 2007, 146, 459. K. Kümmerer, Chemosphere, 2009, 75, 417. Y. Deng, R. Zhao, Cur. Pollution Rep., 2015, 1, 167. A. S. Oliveira, E. M. Saggioro, T. Pavesi, J. C. Moreira, L. F. V. Ferreira, Molecular Photochemistry-Various Aspects, INTECH, 2012, 9.

Aim of my PhD project (Photo)degradation S. M. A. Pinto, C. S. Vinagreiro, V. A. Tomè, G. Piccirillo, L. Damas, M. M. Pereira, JPP, 2019, 23, 1-18. M. J. F. Calvete, G. Piccirillo, C. S. Vinagreiro, M. M. Pereira, Coord. Chem. Rev., 2019, 395, 63-85.

Oxidation Products Homogeneous Degradation of Trimethoprim (TMP) Catalytic Oxidation Oxidation Products H2O2 catalyst 2h Best experimental conditions: [TMP]=1g/L [MnTDCPPs]=0,04g/L [H2O2]final=0,02g/L catalyst L. D. Dias, R. M. B. Carrilho, C. A. Henrique, G. Piccirillo, A. Fernandes, L. M. Rossi, M. F. Ribeiro, M. J. F. Calvete, M. M. Pereira, JPP, 2018, 22, 331-341.

HPLC analysis of oxidation products HPLC-MS analysis I.S. TMP Product Retention Time 4.089 min 6.625 min 8.628 min 13.487 min I.S. Figure. Hplc chromatograms of the TMP degradation after 2h. Method: Phenomenex Luna 5u C18 column (150 x 4.6 mm) reverse phase; 15% CH3OH, 15% CH3CN, 70% CH3COONH4 10mM (pH 9.52) (as mobile phase); flux 0.400 mL min-1; λ=270,8 nm. In collaboration with Prof. Artur Silva and Dr. Monica Válega (University of Aveiro)

Heterogeneous Degradation of Trimethoprim (TMP)

Reutilization test are ongoing Heterogeneous Degradation of Trimethoprim (TMP) Catalytic Oxidation Same oxidation Products H2O2 catalyst 2h Reutilization test are ongoing catalyst

Efficient system for TMP Conclusions Efficient system for TMP catalytic oxidation + H2O2 Aknowledgments