Two-year changes in albumin-to-creatinine ratio across microalbuminuria at baseline. Two-year changes in albumin-to-creatinine ratio across microalbuminuria at baseline. The urine albumin-to-creatinine ratio was ≥17 for men and ≥25 for women. (No microalbuminuria, n = 299; microalbuminuria, n = 23). ■ = baseline, □ = after 2 years of intervention. *P < 0.05 for improvement within groups after 2 years of intervention. †P < 0.05 for improvement between groups after 2 years of intervention. Amir Tirosh et al. Dia Care 2013;36:2225-2232 ©2013 by American Diabetes Association