Knockout of SIRT1 in podocytes aggravates proteinuria and kidney injury in db/db mice. Knockout of SIRT1 in podocytes aggravates proteinuria and kidney.

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Knockout of SIRT1 in podocytes aggravates proteinuria and kidney injury in db/db mice. Knockout of SIRT1 in podocytes aggravates proteinuria and kidney injury in db/db mice. A: The urine albumin-to-creatinine ratio was measured as described in QUANTIFICATION OF URINE ALBUMIN. *P < 0.01 compared with the corresponding time points of mice in other groups (n = 6). B: Kidney histology of mice with periodic acid Schiff (PAS) staining. The representative images are shown. C: Morphometric analysis was performed in these kidney sections with PAS staining for calculation of mesangial/glomerular fraction area. D: Kidney sections also were used for wild-type 1 staining to determine the number of podocytes per glomerulus. *P < 0.01 compared with Pod-Cre+/−;db/m mice; #P < 0.05 compared with Pod-Cre+/−;db/db mice (n = 6). Ruijie Liu et al. Diabetes 2014;63:2440-2453 ©2014 by American Diabetes Association