Signalling specificity in the TGF-β superfamily.

Slides:

Advertisements

Similar presentations

SIGNALING FROM THE CELL SURFACE TO THE NUCLEUS

Advertisements

Shiqiu Li Dr. Scott Stewart Stankunas Lab UO SPUR 2012.

Fractions How many shapes?. Fractions 4 What fraction of this shape is shaded orange?

BMP receptor1A Presented by Jena Buchan

Page 1 What is TGF-β —Creative BioMart. Page 2 The transforming growth facor beta (TGF-β) superfamily is a large family of growth factors named after.

Fig. 4. Effects of lobeglitazone (Lobe) on the transforming growth factor β (TGF-β)/Smad3 signaling pathway in kidney cell lines. (A) Effects of Lobe on.

Figure 1 Simplified scheme of TGFβ signalling

Copyright © 2015 by the American Osteopathic Association.

Figure 5. ALK2 Is Expressed in All MIS Target Tissues Levels of ALK2, ALK6, and MISRII mRNAs were measured in embryonic mouse urogenital ridges (A) and.

A model for the role of ALK-1 and endoglin in normal angiogenesis

inhibits BMP signalling.

Figure 1. Functional classification of positive-acting transcription factors. Major functional groups are shown in black; specific examples are illustrated.

Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface. Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface.

SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Bone Morphogenetic Proteins

Figure 1 Phylogenetic analysis of BMP superfamily molecules

Pathogen Recognition: TLRs Throw Us a Curve

Antonello Pietrangelo Gastroenterology

Bio 3411 Lecture IV. Mechanisms of Neural Development

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Cell signaling and cancer

Volume 11, Issue 3, Pages (March 2003)

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Neurol. doi: /nrneurol

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Bone Morphogenetic Proteins and articular cartilage

Volume 142, Issue 4, Pages (August 2010)

The Role of Smads in Skin Development

A New Twist in Smad Signaling

Volume 46, Issue 5, Pages (June 2012)

Computing at the Front-End by Receptor Networks

Heterozygous disruption of activin receptor–like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy José.

Barbara Jung, Jonas J. Staudacher, Daniel Beauchamp Gastroenterology

TGF-β Receptor I/ ALK-5 and Pancreatic and Biliary Cancer

GDF11 and the Mythical Fountain of Youth

Bone Morphogenetic Proteins and articular cartilage

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

Volume 11, Issue 3, Pages (March 2003)

Family of calibrated models recovered for immediate‐early signalling downstream of seven transmembrane receptors in HepG2 cells. Family of calibrated models.

Genes frequently mutated in colorectal cancer and their relationships with miRNAs. Genes frequently mutated in colorectal cancer and their relationships.

Characterization of GDF11 signalling through type I and type II receptors. Characterization of GDF11 signalling through type I and type II receptors. Gene.

Non-Smad signalling. Non-Smad signalling. The canonical Smad pathway starting from the ligand-receptor complex and ending in the nucleus is illustrated.

Nervous system regulation of epithelial and epidermal innate immunity in C. elegans. Nervous system regulation of epithelial and epidermal innate immunity.

(A) The canonical Smad pathway.

Notch pathway components in serial sections of the human colon.

Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation.

IQGAPs localize at the tips of axons in hippocampal neurons.

Proteins associated with PfSec13.

Fig. 2. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Blocking of BMP signaling,

Directed differentiation of hPSCs.

Components and outcomes of selected TNF-superfamily signalling pathways. Components and outcomes of selected TNF-superfamily signalling pathways. (Left)

The TGFβ large latent complex (LLC).

Niels Grote Beverborg et al. JCHF 2018;6:

The AUX and PIN auxin carrier proteins are transported by both ESCRT-dependent and ESCRT-independent pathways. The AUX and PIN auxin carrier proteins are.

Model for TGF-β-induced myofibroblast differentiation involving MKL1 isoform-specific activities. Model for TGF-β-induced myofibroblast differentiation.

CENP-F staining in prometaphase and metaphase spermatocytes from B6 and Rb/+ mice. CENP-F staining in prometaphase and metaphase spermatocytes from B6.

Smad signalling centres.

Transcriptional regulation by Smads.

Smad oligomerisation. Smad oligomerisation. Pictorial representation of the plasma membrane receptor kinases that phosphorylate the C-termini of R-Smads.

Model of the role of Vav proteins in apical maturation.

Detection of phosphorylated Smad2/3 (pSmad2/3) in the skin of wild-type and transgenic animals during the first hair cycle. Detection of phosphorylated.

The dynamic interplay between the lung extracellular matrix (ECM) and resident cells, with transforming growth factor (TGF)-β1 at its centre. The dynamic.

Influence of the tumor microenvironment on FL

Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades.

Volume 24, Issue 1, Pages 7-8 (July 2016)

TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia

Hippo-based model. Hippo-based model. Arrows point out the direction of signaling: in orange, the YAP signaling effects on p73 driven by c-Abl, in blue.

Presentation transcript:

Signalling specificity in the TGF-β superfamily. Signalling specificity in the TGF-β superfamily. Classification of the mammalian Smad signalling cascade into activin–TGF-β (maroon) and BMP (blue) pathways. Representative examples of mammalian ligands (pink shading), type II receptors (red shading), type I receptors (orange shading), R-Smads (green shading), Co-Smads (bright green shading) and I-Smads (grey shading) are depicted in pathways linked by arrows or signs of inhibition. Bifurcation of the TGF-β pathway at the level of type I receptors towards both TGF-β and BMP Smads is marked by an asterisk. Nomenclature of proteins not detailed in the text are growth and differentiation factors (GDFs), Mullerian inhibiting substance (MIS), activin type II and type IIB receptor (ActRII/IIB), TGF-β type II receptor (TβRII), BMP type II receptor (BMPRII), MIS type II receptor (MISRII), activin receptor-like kinases 1 to 6 (ALK1-ALK6). For references see ten Dijke et al. (ten Dijke et al., 2000). Aristidis Moustakas et al. J Cell Sci 2001;114:4359-4369 © The Company of Biologists Limited 2001