Model for insulin-mediated inhibition of adrenomedullin transcription and its consequences on adipocyte differentiation. Model for insulin-mediated inhibition.

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Model for insulin-mediated inhibition of adrenomedullin transcription and its consequences on adipocyte differentiation. Model for insulin-mediated inhibition of adrenomedullin transcription and its consequences on adipocyte differentiation. A: Adrenomedullin is synthesized in the absence of insulin signaling. Adrenomedullin acts by an unknown mechanism to decrease the mRNA expression of adipocyte-specific transcription factors, whereby it decreases adipogenesis. B: Insulin inhibits adrenomedullin gene expression by recruiting unknown trans-acting factor(s) to two negative IREs. Bold red arrows correspond to fully activated signals. Thin blue arrows symbolize partially inhibited signals. IRS1–4, insulin receptor substrate 1–4; PI3K, phosphatidyl inositol 3-kinase. Romain Harmancey et al. Diabetes 2007;56:553-563 ©2007 by American Diabetes Association