DNA polymerase adds new nucleotides to 3’-OH; DNA strands grow 5'3'

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Presentation transcript:

DNA polymerase adds new nucleotides to 3’-OH; DNA strands grow 5'3'

DNA replication proceeds bidirectionally from an origin of replication http://www.web-books.com/MoBio/Free/Ch7A.htm

Because DNA synthesis always occurs 5'3', the two strands replicate differently

DNA replication complex http://www.nature.com/nature/journal/v421/n6921/box/nature01407_bx1.html

More complex views of DNA replication The trombone model http://www.mcb.harvard.edu/Losick/images/Tro mboneFINALd.swf Molecular visualization of DNA replication

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