Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD

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Presentation transcript:

Physical activity and exercise in asthma: Relevance to etiology and treatment Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD Journal of Allergy and Clinical Immunology Volume 115, Issue 5, Pages 928-934 (May 2005) DOI: 10.1016/j.jaci.2005.01.033 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Proposed factors influencing the patency of bronchioles. Excess mucus and edema caused by poor mucociliary clearance from decreased epithelial stimulation secondary to decreased activity. Smooth muscle latching and decreased chest wall force from decreased deep inspiration and sigh rate. Collagen deposition from chronic inflammation. Adapted from a slide by R. R. Schellenberg. Journal of Allergy and Clinical Immunology 2005 115, 928-934DOI: (10.1016/j.jaci.2005.01.033) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Axial chest hyperpolarized helium magnetic resonance scan of a patient with mild asthma before (A) and after (B) exercise, demonstrating acute bronchoconstriction and ventilation defects. Journal of Allergy and Clinical Immunology 2005 115, 928-934DOI: (10.1016/j.jaci.2005.01.033) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions