Lecture 9 Slides rh
LIPID CATABOLISM
lipid menagerie phospholipid triglyceride
from McDonalds to Metabolism… fig17-1
from McDonalds to Metabolism…
The chylomicron: a lipoprotein fig17-2
mobilization of glycerol fig17-4
connecting the FA to CoA-SH fig17-5
connecting the FA to CoA-SH good leaving group fig17-5
fig 19-1
Carnitine: Charon* of the matrix! * you know, the boatman on the River Styx
Carnitine: Charon* of the matrix! * you know, the boatman on the River Styx
Transport of acyl-carnitine into the matrix rate-limiting step for oxidation of FAs fig17-6
oxidation of fatty acids: three steps, one new… fig17-7
b-oxidation: taking it two carbons at a time fig17-8
iterated metabolic pathway fig17-8
b-oxidation challenges… monounsaturated FA odd-carbon FA
b-oxidation challenges… monounsaturated FA polyunsaturated FA odd-carbon FA
b-oxidation of a mono- unsaturated fatty acid fig17-9
b-oxidation challenges… monounsaturated FA polyunsaturated FA odd-carbon FA
what about 3-carbon leftovers? fig17-11
what about 3-carbon leftovers? fig17-11
what about 3-carbon leftovers? fig 17-11
the coenzyme B12 reaction box17-2
deoxyadenosyl cobalomin or coenzyme B12 box17-2
box17-2
comparison of FA oxidation mitochondria vs. peroxisomes catalase box17-13
fatty acid metabolism in seeds… fig17-14
enzyme evolution in fatty acid oxidation one protein fig17-15
ketone bodies fig17-16
formation of ketone bodies from Ac-CoA fig17-18
formation of ketone bodies from Ac-CoA fig17-18
formation of ketone bodies from Ac-CoA fig17-18
formation of ketone bodies from Ac-CoA fig17-18
formation of ketone bodies from Ac-CoA fig17-18
metabolism of a ketone body fig17-19
fig17-19
fig17-19
fig17-19
liver synthesis of ketone bodies when TCA activity is low fig17-20