Peroxisome speeds were slower in patient and control cells.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

TMZ and Ara-C treatment of slice co-cultures.

Scanning electron microscopy analysis of EGK-I to -V chick embryos.

Structure of abbreviated dystrophins.

Distribution of percentage compliance during the intervention period for Sch-I and Sch-V. Distribution of percentage compliance during the intervention.

Leukemia involves the accumulation of ISP CD8+T-cells and blockages in B-cell development. Leukemia involves the accumulation of ISP CD8+T-cells and blockages.

Morphological alterations in pancreatic islets demonstrate a compensatory response to HFHC diet and STZ-induced β-cell loss. Morphological alterations.

Percentage fractions of (β-Gal+) PCs in 32-week-old heterozygous females differ between cerebellar lobules affected and spared from degeneration of Purkinje.

BTN1 mRNA level in response to extracellular pH determined by comparative RT2PCR. BTN1mRNA level in response to extracellular pH determined by comparative.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

A highly conserved six-amino-acid region in the C-terminal CT domain of MARCH8 is responsible for its ability to downregulate TfR. A highly conserved six-amino-acid.

Alterations in Notch signaling affect the frequency of intermediate and main IHBD branches. Alterations in Notch signaling affect the frequency of intermediate.

Rhomboid-7, Pink1 and Omi physically interact in the mitochondria

A Drosophila cell culture model to study VAP(P58S) aggregation.

OA and related amines modulate motility and length of schistosomula.

Dictyostelium expressing N-APC lack the ability to maintain direction during migration. Dictyostelium expressing N-APC lack the ability to maintain direction.

Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer. Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer.

Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Concentration of biomarkers of haemostasis.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Enterocytes fail to migrate consistently towards the villus tip in live APCMin/+ tissue. Enterocytes fail to migrate consistently towards the villus tip.

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Hipk induces cell spreading.

Patient and control ONS cells had very large differences in gene expression. Patient and control ONS cells had very large differences in gene expression.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

Working hypothesis of histone lysine crotonylation in kidney injury.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Obesity affected the metabolic response to stroke.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Expression data confirm and extend existing knowledge

Wound recruitment of melanocytes requires innate immune cells.

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Hipk induces overgrowths in Drosophila imaginal discs.

Fig. 7. Lhx1-RNAi reduces the eye size

Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.

Elevated expression of vegfaa in hemangiosarcoma.

The effect of TDP-43A315T expression on dendrite spine development.

Distribution and extent of expression.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

TWEAK increases histone crotonylation in kidney tubular cells.

Elevation of ERK downstream signaling is associated with tumor formation in the bladder and in papilloma formation. Elevation of ERK downstream signaling.

Cellular reaction to intraventricular DMSO injection.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Rgs16::GFP expression in pancreatic neoplasia.

Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.

Effect of Dipy on the expression of chondrogenic markers.

Chd1 expression and CHD1 localization during mouse preimplantation development. Chd1 expression and CHD1 localization during mouse preimplantation development.

The expression of two forms of N-cadherin.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Altered intracellular distributions of acetylated α-tubulin, mitochondria and peroxisomes. Altered intracellular distributions of acetylated α-tubulin,

Notch signaling affects the frequency of different branch diameters in proportion to the original contribution. Notch signaling affects the frequency of.

Fig. 5. Co-expression analyses of disease mutations in YFP-RPGRIP1α1 with wild-type RFP-RPGR1–19 or RFP-RPGRORF15 in COS7 cells.YFP-RPGRIP1α1 with disease-associated.

WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates TfR. WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates.

The absence of host Fbln5 results in increased apoptosis and decreased proliferation in Pan02 tumors. The absence of host Fbln5 results in increased apoptosis.

Effects of paclitaxel and vinblastine.

Effect of siRNA transfection on colony formation by Renca cells.

BMOL3 LPCs can differentiate towards the hepatocyte lineage.

2DG suppresses of lamellipodia and filopodia and causes disorganization of F-actin filaments in murine endothelial cells. 2DG suppresses of lamellipodia.

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Presentation transcript:

Peroxisome speeds were slower in patient and control cells. Peroxisome speeds were slower in patient and control cells. Frequency distributions of peroxisomes in different speed classes are shown for control cells (open bars; n=7 individuals, 10 cells per individual) and patient cells (filled bars; n=6 individuals, 10 cells per individual). Peroxisome speeds were quantified every 2 seconds for 2 minutes and grouped in speed classes expressed as the percentage of peroxisomes in each speed class as a percentage of the total number of peroxisomes for each group (control cells, n=13,871 peroxisomes; patient cells, 10,529 peroxisomes). Greger Abrahamsen et al. Dis. Model. Mech. 2013;6:489-502 © 2013. Published by The Company of Biologists Ltd