Volume 59, Issue 3, Pages (March 2001)

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Volume 59, Issue 3, Pages 1114-1120 (March 2001) Leptin is a negative acute phase protein in chronic hemodialysis patients Burl R. Don, Laura M. Rosales, Nathan W. Levine, William Mitch, George A. Kaysen Kidney International Volume 59, Issue 3, Pages 1114-1120 (March 2001) DOI: 10.1046/j.1523-1755.2001.0590031114.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Serum amyloid A (SAA; A) and interleukin-6 (IL-6; B) levels at minimum and maximum levels of C-reactive protein (CRP). Both SAA and IL-6 increased significantly when CRP increased as analyzed by Wilcoxon signed rank test. Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Ceruloplasmin (A) and α1-acid glycoprotein (α1 AG) (B) levels at minimum and maximum levels of CRP. Both ceruloplasmin and α1 AG increased significantly when CRP increased as analyzed by paired t test. Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Leptin (A), albumin (B), and transferrin (C) at minimum and maximum levels of CRP. All three proteins decreased significantly when CRP increased as analyzed by Wilcoxon signed rank test (leptin) and paired t test (albumin and transferrin). Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Regression analysis comparing the changes in CRP levels (&Dgr;CRP) with changes in serum amyloid A (&Dgr;SAA; μg/mL; A), ceruloplasmin (mg/dL; B) and α1-acid glycoprotein (α1 AG; mg/dL; C). There is a significant positive correlation between changes in CRP levels and these three positive acute phase proteins. Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Regression analysis comparing the changes in IL-6 (pg/mL) with changes in CRP levels (mg/dL). There is a significant positive correlation between changes in IL-6 with changes in CRP (r = 0.509; P < 0.005). Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 6 Regression analysis comparing the changes in CRP levels (&Dgr;CRP; mg/dL) with changes in leptin (ng/mL; A), albumin (g/dL; B), and transferrin (mg/dL; C). There is a significant negative correlation between changes in CRP levels and changes in these three proteins. Kidney International 2001 59, 1114-1120DOI: (10.1046/j.1523-1755.2001.0590031114.x) Copyright © 2001 International Society of Nephrology Terms and Conditions