Volume 131, Issue 6, Pages (December 2006)

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Volume 131, Issue 6, Pages 1706-1716 (December 2006) Dietary Factors and Biomarkers Involved in the Methylenetetrahydrofolate Reductase Genotype–Colorectal Adenoma Pathway María Elena Martínez, Patricia Thompson, Elizabeth T. Jacobs, Edward Giovannucci, Ruiyun Jiang, Walt Klimecki, David S. Alberts Gastroenterology Volume 131, Issue 6, Pages 1706-1716 (December 2006) DOI: 10.1053/j.gastro.2006.09.010 Copyright © 2006 AGA Institute Terms and Conditions

Figure 1 Proposed pathway for the effect of MTHFR genotypes on risk of colorectal adenoma. Polymorphisms in the MTHFR gene result in high homocysteine concentrations. If homocysteine is not removed, SAH accumulation will occur, resulting in a higher SAH:SAM ratio; higher concentrations of these 2 products can lead to DNA hypomethylation. This pathway is especially important in the presence of low folate status. Gastroenterology 2006 131, 1706-1716DOI: (10.1053/j.gastro.2006.09.010) Copyright © 2006 AGA Institute Terms and Conditions