Filaggrin mutations, atopic eczema, hay fever, and asthma in children

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Presentation transcript:

Filaggrin mutations, atopic eczema, hay fever, and asthma in children Stephan Weidinger, MD, Maureen O'Sullivan, MD, Thomas Illig, PhD, Hansjörg Baurecht, MSc, Martin Depner, MSc, Elke Rodriguez, MSc, Andreas Ruether, PhD, Norman Klopp, PhD, Christian Vogelberg, MD, Stephan K. Weiland, MD, W.H. Irwin McLean, PhD, DSc, FRSE, Erika von Mutius, MD, Alan D. Irvine, MD, Michael Kabesch, MD Journal of Allergy and Clinical Immunology Volume 121, Issue 5, Pages 1203-1209.e1 (May 2008) DOI: 10.1016/j.jaci.2008.02.014 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Nasal filaggrin expression. Sections of vestibular skin (A), transitional epithelium (B), and respiratory mucosa (C). In the vestibular skin, staining is identical to the pattern observed in normal hair-bearing skin with strong granular staining in the granular layer and more diffuse staining of the stratum corneum. In transitional and respiratory nasal epithelia, no typical filaggrin staining is demonstrable. There is minimal edge artefact that is not significant. All original magnifications ×100. Journal of Allergy and Clinical Immunology 2008 121, 1203-1209.e1DOI: (10.1016/j.jaci.2008.02.014) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions