Fig. 2 IT1t prevents TLR7-mediated inflammation in pDCs.

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Fig. 2 IT1t prevents TLR7-mediated inflammation in pDCs. IT1t prevents TLR7-mediated inflammation in pDCs. Isolated human pDCs were cultured with R848 (5 μg/ml) in the presence or absence of IT1t (20 μM). Total RNA from the cells was isolated and analyzed using the NanoString nCounter. (A) PCA was performed on the basis of 136 genes from the array differentially expressed between the NS (gray) and the R848 (orange) conditions. (P < 0.05, fold change > 2). (B) Heat map represents mRNA fold increase of the 136 genes significantly differently expressed between the NS and the R848 condition (P < 0.05, fold change > 2). (C) Pie chart representation of the promoters associated with genes significantly up-regulated between the NS and the stimulated (R848) condition and between the NS and the R848 + IT1t condition (P < 0.05, fold change > 2). The red parts represent ISGs (ISGF3 promoter) and the type I IFN (IRF7 promoter). Areas of the pie slices are representative of the number of genes. (D) mRNA levels of various genes were quantified by RT-qPCR for confirmation in two healthy donors. (E) Heat map represents the mRNA fold increase of 85 genes differently expressed between the NS (gray) and the IT1t (green) condition (P < 0.05, fold change > 2.5). (F) Pie chart represents the impact on inflammation of differently expressed genes between NS and IT1t. NS, nonstimulated. Nikaïa Smith et al. Sci Adv 2019;5:eaav9019 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).