Volume 66, Issue 4, Pages (October 2004)

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Volume 66, Issue 4, Pages 1465-1470 (October 2004) Uric acid and the state of the intrarenal renin-angiotensin system in humans Todd S. Perlstein, Olga Gumieniak, Paul N. Hopkins, Laine J. Murphey, Nancy J. Brown, Gordon H. Williams, Norman K. Hollenberg, Naomi D.L. Fisher Kidney International Volume 66, Issue 4, Pages 1465-1470 (October 2004) DOI: 10.1111/j.1523-1755.2004.00909.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 The renal plasma flow (RPF) response to angiotensin II (Ang II) decreases with increasing quartile of uric acid. Bars represent mean response per quartile, error bars are ± standard error. Groups compared by analysis of variance (ANOVA). Labeled are the mean and range of serum uric acid concentration for each quartile. Kidney International 2004 66, 1465-1470DOI: (10.1111/j.1523-1755.2004.00909.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Serum uric acid is negatively correlated with baseline renal plasma flow (RPF) (r=-0.30, P < 0.001). Kidney International 2004 66, 1465-1470DOI: (10.1111/j.1523-1755.2004.00909.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 The observed and predicted renal plasma flow (RPF) response to angiotensin II (Ang II) plotted against the serum uric acid level in women and men. Women tend to have a higher serum uric acid level and a higher RPF to Ang II than men. The prediction lines are overlapping, indicating that the relationship between the RPF response to Ang II and the serum uric acid level is essentially identical in men and women. Kidney International 2004 66, 1465-1470DOI: (10.1111/j.1523-1755.2004.00909.x) Copyright © 2004 International Society of Nephrology Terms and Conditions