PEDF blockage improved the reduced numbers of circulating CD34+/CD133+/Flk-1+ cells and impaired EPC functions, including migration, adhesion, and tube.

Slides:

Advertisements

Similar presentations

ABAE positive cells 6h after treatment

Advertisements

بهداشت فردي.

T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. T cell receptor Vβ (TCR-Vβ) expression.

Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its α receptor by Francesco De.

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

Figure 1 Peripheral blood leukocyte subset counts during dimethyl fumarate treatmentComplete blood cell counts were obtained at baseline (n = 34) and at.

Molecular mechanism of STING-mediated inhibition of the mTORC1 pathway

IBD development correlates with peripheral T cell activation in DNR mice. IBD development correlates with peripheral T cell activation in DNR mice. (A)

PD-1–PD-L1 axis is highly expressed and is not IFNγ-dependent in a subcutaneous murine model of PDA. A, experimental design for establishment of subcutaneous.

Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.

KIF18A sNL variants accumulate as well as WT on peripheral K-fibers.

TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.

Fig. 2. p85β regulates cell adhesion

Setdb1 has cell-intrinsic functions in B cell development.

Robo3 in the GnRH neuronal system.

Analysis of peripheral blood CD4+CD25+ T-cells after B6

Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. A:

Ectopic expression of wt-DAO, but not the inactive mutant, promotes senescence. Ectopic expression of wt-DAO, but not the inactive mutant, promotes senescence.

Gene expression in islets isolated from diabetic mice.

P38 activation mediates chronic insulin-induced IRS1 and IRS2 degradation and is involved in myocardial insulin resistance in vitro. p38 activation mediates.

TSG-6 suppressed APC activation in vitro and in vivo.

Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice. Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice.

IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.

Loss of protection by linagliptin against obesity-related inflammation and insulin resistance in MIP-1α−/− mice. Loss of protection by linagliptin against.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

Glucose tolerance in WT and TRPM2-KO mice.

ΑGLP-1R−/− mice show glucose intolerance and disturbed glucagon secretion in response to i.p. glucose administration. αGLP-1R−/− mice show glucose intolerance.

MiRNA expression profiling in adipocytes from wild-type (WT) and leptin-deficient ob/ob mice. miRNA expression profiling in adipocytes from wild-type (WT)

Expression of IRS2 ameliorates the effects of ATF3 in cultured β-cells

Higher levels of PEDF-impaired skin structure and function.

Reduced OXPHOS expression and increased UCP expression.

Atrasentan reduces albuminuria in diabetic apoE KO mice.

Diabetes development in B6.H-2g7/RIP-B7.1 and control mice.

Oxidative stress, superoxide, and Pdx-1 levels in pancreatic islets of diabetic mice. Oxidative stress, superoxide, and Pdx-1 levels in pancreatic islets.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice. Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice.

AKT thr308 phosphorylation related to total AKT2 protein in SOL muscle (m. soleus) (A) and EDL muscle (m. extensor digitorum longus) (D) and AKT ser472.

Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Energy stores in quadriceps muscles.

Functional characterization of CD4+ T-cells with various antigen specificities after transduction with FoxP3. Functional characterization of CD4+ T-cells.

Transgenic c-Maf mediates upregulation of type 2 cytokines in NOD CD4, but not CD8, cells. Transgenic c-Maf mediates upregulation of type 2 cytokines in.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT

d-PA, unlike n-PA, impairs EPC functions.

RT-PCR quantification of ubiquitination gene transcripts in rat islets exposed to 2.8 or 16.7 mmol/l glucose for 2 h (A) or 24 h (B). RT-PCR quantification.

Blood glucose levels in chicken embryos.

Decreased M1 and increased M2 macrophages in eWAT and liver of DIO mice due to linagliptin administration. Decreased M1 and increased M2 macrophages in.

Fig. 1 Neu1−/− fibroblasts have characteristics of myofibroblasts.

Fig. 6 SNP rs is a functional SNP in 22Rv1 cells.

Effects of GIP and GLP-1 infusion on MR-proANP levels.

Effect of HA on hematopoietic recovery in tumor-bearing mice.

Fig. 2 Phenotypic analyses of Bcl11b-deficient Treg cells.

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. LNCaP,

Combination of miR-520d-3p and EphA2 siRNA treatment shows enhanced EphA2 inhibition and antitumor efficiency in vitro. Combination of miR-520d-3p and.

Tregs preferentially regulate TH2 cytokines in skin.

Fig. 4 IP6K1-mediated polyP production by platelets plays a critical role in LPS-induced NPA formation. IP6K1-mediated polyP production by platelets plays.

Effects of metformin on GLP-1(7–36)amide degradation in vitro shown by GLP-1(7–36)amide concentrations (% variation from time 0) after a 30-min incubation.

Immunophenotypic analysis of TILs in B16 and K1735 melanoma following combination therapy with antibodies targeting PS and PD-1. Immunophenotypic analysis.

Effect of SPINDLIN1 protein on cancer cell proliferation and invasion.

VEGF165 stimulates migration of HMVECs

SPARC is required for spontaneous metastasis

In vitro lymphokine responses of mesenteric LN cells from S

Loss of polarity gene Dlg1 leads to an expansion of C'-1 stage cells during pre-B cell differentiation. Loss of polarity gene Dlg1 leads to an expansion.

Blocking αvβ3/galectin-3 binding with GCS-100 selectively kills KRAS-addicted lung cancer cells. Blocking αvβ3/galectin-3 binding with GCS-100 selectively.

Supplementary Figure 1. The extrinsic acquisition of CD80 does not affect the cytotoxicity of Ag-specific memory CD8+ T cells. The LG and SP were obtained.

Validation of KMT2D function in MM23, MM2, and MM25 PDXs

Ezh2 inactivation inhibits initiation/progression of CML and establishment of secondary leukemia from existing LICs. A, protocol for induction of Ezh2.

DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.

Presentation transcript:

PEDF blockage improved the reduced numbers of circulating CD34+/CD133+/Flk-1+ cells and impaired EPC functions, including migration, adhesion, and tube formation of diabetic mice. PEDF blockage improved the reduced numbers of circulating CD34+/CD133+/Flk-1+ cells and impaired EPC functions, including migration, adhesion, and tube formation of diabetic mice. A–D: Representative FACS results of peripheral blood are shown. E–H: Quantification of CD34+/Flk-1+ and CD133+/Flk-1+ cells in peripheral blood (mean ± SD, n = 10 animals/group, *P < 0.05, **P < 0.01). db/db+IgG vs. db/db+PEDF Ab (E), NDM+GST vs. NDM+PEDF (F), PEDF KO vs. WT (G), PEDF KO (DM) vs. WT (DM) (H). I: Representative in vitro migration results are shown. J–L: Migration cell numbers (representative cohort of n = 5 animals/group, **P < 0.01). M: Representative in vitro adhesion results are shown. N–P: Adhesion assay cell numbers (representative cohort of n = 5 animals/group, *P < 0.05, **P < 0.01). Q: Representative in vitro tube formation results are shown. R–T: Tube formation branch point counting (representative cohort of n = 5 animals/group, **P < 0.01). Statistical significance was considered at P < 0.05. All data were expressed as the mean ± SD. Weiwei Qi et al. Diabetes 2015;64:1407-1419 ©2015 by American Diabetes Association