Fig. 2 Transcriptome-wide distribution of m6A revealed by m6A-REF-seq.

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Fig. 2 Transcriptome-wide distribution of m6A revealed by m6A-REF-seq. Transcriptome-wide distribution of m6A revealed by m6A-REF-seq. (A) The analysis pipeline of m6A-REF-seq data. (B) The snapshot of sequencing reads shows a known m6A site in 18S rRNA. (C) Overlap sites among three replicates after removing RNA secondary structure. (D) The overall shift of methylation ratio after FTO treatment. The value of methylation change indicates the methylation ratio of each m6A site in MazF minus that after FTO treatment. (E) Transcriptome-wide distribution of m6A. Pie chart shows the percentages of m6A sites located within CDS, 5′UTR, and 3′UTR. (F) Single-base m6A sites from m6A-REF-seq show a typical transcriptome-wide distribution pattern of m6A. (G) Overlap of m6A sites to the m6A peaks identified by antibody-based method. (H) The proportion of motifs containing m6A sites. The red square includes the RRACA motif and the green square includes the DRACA motif. Zhang Zhang et al. Sci Adv 2019;5:eaax0250 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).