A: Scanning electron micrograph illustrating the fenestrated glomerular endothelium. A: Scanning electron micrograph illustrating the fenestrated glomerular.

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A: Scanning electron micrograph illustrating the fenestrated glomerular endothelium. A: Scanning electron micrograph illustrating the fenestrated glomerular endothelium. B: Scanning electron micrograph illustrating interdigitating podocyte foot processes wrapped around the glomerular capillary wall. C: Transmission electron micrograph showing the structure of the glomerular filtration barrier composed of fenestrated endothelium, glomerular basement membrane, and interdigitating podocytes bridged by a molecular slit diaphragm. D: Transmission electron micrograph of the glomerular filtration barrier from a diabetic endothelial NO synthase–deficient mouse showing podocyte foot process effacement in the presence of normal glomerular endothelial fenestrations and ultrastructure. Ferhan S. Siddiqi, and Andrew Advani Diabetes 2013;62:3647-3655 ©2013 by American Diabetes Association