Switches, Switches, Every Where, In Any Drop We Drink

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Switches, Switches, Every Where, In Any Drop We Drink Jérôme Bonnet, Drew Endy Molecular Cell Volume 49, Issue 2, Pages 232-233 (January 2013) DOI: 10.1016/j.molcel.2013.01.005 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Architectural Adjacencies within Natural Genetic Switches (A) Abstraction of control relationships as revealed by Broussard et al. (2013). Integration stabilizes the repressor protein by removing a site-specific ssrA proteolysis epitope (solid blue, positive regulation). Repressor inhibits lytic functions (solid black, negative regulation). Cro inhibits lysogenic functions, albeit via a currently unknown mechanism (dashed black, negative regulation). (B) As in (A) but via different molecular couplings more akin to the bacteriophage lambda-switch architecture. Repressor (CI) again inhibits lytic functions (solid black, negative regulation, red ORF shading) but also autoregulates repressor and integrase levels via a point substitution (A135E) that enables transcription activation (solid blue, positive regulation, green ORF shading). Cro still inhibits lysogenic functions via transcription repression (dashed black, negative regulation). Molecular Cell 2013 49, 232-233DOI: (10.1016/j.molcel.2013.01.005) Copyright © 2013 Elsevier Inc. Terms and Conditions