Nisha Charkoudian, PhD, Jennifer A. Rabbitts, MBChB

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Presentation transcript:

Sympathetic Neural Mechanisms in Human Cardiovascular Health and Disease Nisha Charkoudian, PhD, Jennifer A. Rabbitts, MBChB Mayo Clinic Proceedings Volume 84, Issue 9, Pages 822-830 (September 2009) DOI: 10.4065/84.9.822 Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Electrocardiogram (ECG), integrated sympathetic neurogram, and plot of beat-to-beat arterial pressure (AP) (as measured by a brachial artery catheter) from a healthy person. The figure shows the dynamic relationship between AP and muscle sympathetic neural activity (MSNA). The shading highlights an example of a transient decrease in AP that elicits an increase in MSNA via the baroreflex. This increase causes vasoconstriction, which in turn increases AP and leads to a reflex decrease in MSNA. Mayo Clinic Proceedings 2009 84, 822-830DOI: (10.4065/84.9.822) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Electrocardiogram (ECG), integrated sympathetic neurogram, and plot of beat-to-beat arterial pressure (AP) from a healthy person. The ECG tracing shows a premature ventricular contraction that is associated with an ineffective beat. The subsequent decrease in diastolic pressure elicits a large reflex burst of muscle sympathetic neural activity (MSNA). The arrow indicates the relationship between the low diastolic pressure and the elicited burst of MSNA. Mayo Clinic Proceedings 2009 84, 822-830DOI: (10.4065/84.9.822) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 3 Resting values for muscle sympathetic neural activity (MSNA) and mean arterial pressure in 41 healthy men. The figure shows the absence of an association between these variables. Although MSNA values range widely among healthy persons, the arterial pressure levels are not consistently higher among persons with very high MSNA than among those with much lower MSNA. Mayo Clinic Proceedings 2009 84, 822-830DOI: (10.4065/84.9.822) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions