Profiling of the TCRB-MYB cases by large-scale gene expression analysis. Profiling of the TCRB-MYB cases by large-scale gene expression analysis. (A) Heat.

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Profiling of the TCRB-MYB cases by large-scale gene expression analysis. Profiling of the TCRB-MYB cases by large-scale gene expression analysis. (A) Heat map representation of the hierarchical clustering of genes and samples using expression values for genes expressed differentially between the 4 TCRB-MYB cases and the SIL-TAL1, TLX1, and TLX3 cases (gene list in Table S1). One thymus sample and 4 T-cell lines are also included in the analysis. Cytogenetic/genomic annotations are as follows: Y indicates TCRB-MYB; L, TLX3; E, TLX1; and S, SIL-TAL1. Oncogenic groups: Y indicates TCRB-MYB; H, HOX-related; T, TAL-related; and c, cell lines.38 Oncogene expression levels are shown as follows: TAL1 positive indicates range from 1 to 6; −, not analyzed; others are negative. LMO1 and LMO2: P indicates positive; −, not analyzed; others are negative. Data were normalized as described38 and redundant probe sets were masked. The 4 TCRB-MYB cases (boxed in pink) are included in a cluster of cases indicated in blue, together with 3 cell lines (CCRF-CEM, Jurkat, and HSB2), the normal thymus sample, and a SIL-TAL case (TL29). Representative genes from the 3 major clusters are shown, and ectopic genes are indicated in red. (B) Average expression (± SD) of the genes that characterize the TCRB-MYB and cell line cluster. This cluster is specifically enriched in genes linked to cell cycle, cell proliferation, and mitosis, according to Gene Ontology (GO) terms (Table S2). Emmanuelle Clappier et al. Blood 2007;110:1251-1261 ©2007 by American Society of Hematology