Treatment of airway inflammation improves exercise pulmonary gas exchange and performance in asthmatic subjects Hans C. Haverkamp, PhD, Jerome A. Dempsey,

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Presentation transcript:

Treatment of airway inflammation improves exercise pulmonary gas exchange and performance in asthmatic subjects Hans C. Haverkamp, PhD, Jerome A. Dempsey, PhD, David F. Pegelow, MS, Jordan D. Miller, PhD, Lee M. Romer, PhD, Marcus Santana, MD, Marlowe W. Eldridge, MD Journal of Allergy and Clinical Immunology Volume 120, Issue 1, Pages 39-47 (July 2007) DOI: 10.1016/j.jaci.2007.03.013 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Identity plots comparing individual changes in Pao2 (A), Paco2 (B), AaDo2 (C), and Sao2 (D) measured during prolonged exercise before (pre-trt) and after (post-trt) treatment with placebo (PL) or ICS. Journal of Allergy and Clinical Immunology 2007 120, 39-47DOI: (10.1016/j.jaci.2007.03.013) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Group mean exercise data for the placebo (PL) and ICS groups before (pre-trt) and after (post-trt) the treatment period: Pao2 (A), Paco2 (B), AaDo2 (C), Sao2 (D), and arterial blood pH (E). Bars are means ± SDs. ∗Significant difference between pretreatment and posttreatment values within a group (P < .05). Journal of Allergy and Clinical Immunology 2007 120, 39-47DOI: (10.1016/j.jaci.2007.03.013) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Exercise tidal flow-volume loop and resting flow-volume loop plotted within the MFVL from the pretreatment and posttreatment studies for 2 subjects in the ICS group. Also shown are the pretreatment and posttreatment exercise responses for Pao2, Paco2, AaDo2, Sao2, and EELV/TLC ratio. See the Online Repository at www.jacionline.org for detailed information on this figure. Journal of Allergy and Clinical Immunology 2007 120, 39-47DOI: (10.1016/j.jaci.2007.03.013) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions