Hartzell V Schaff, MD, Thierry P Carrel, MD, W. R

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Presentation transcript:

Paravalvular leak and other events in silzone-coated mechanical heart valves: a report from AVERT Hartzell V Schaff, MD, Thierry P Carrel, MD, W.R.Eric Jamieson, MD, Kent W Jones, MD, Juán José Rufilanchas, MD, Denton A Cooley, MD, Roland Hetzer, MD, Frank Stumpe, MD, Daniel Duveau, MD, Patterson Moseley, MD, Wim Jan van Boven, MD, Gary L Grunkemeier, PhD, Elizabeth D Kennard, PhD, Richard Holubkov, PhD The Annals of Thoracic Surgery Volume 73, Issue 3, Pages 785-792 (March 2002) DOI: 10.1016/S0003-4975(01)03442-7

Fig 1 Kaplan-Meier curves showing freedom from reoperation for valve explant during the first 2 years postoperatively (Postop). The Annals of Thoracic Surgery 2002 73, 785-792DOI: (10.1016/S0003-4975(01)03442-7)

Fig 2 Kaplan-Meier curves showing freedom from major paravalvular leak for patients having aortic valve replacement (A) and mitral valve replacement (B). (Postop = postoperative.) The Annals of Thoracic Surgery 2002 73, 785-792DOI: (10.1016/S0003-4975(01)03442-7)

Fig 3 Kaplan-Meier curves showing freedom from thromboembolism during the first 2 years postoperatively (Postop). The Annals of Thoracic Surgery 2002 73, 785-792DOI: (10.1016/S0003-4975(01)03442-7)

Fig 4 Linearized rates of thromboembolism (A) and stroke (B). Risks of thromboembolism were higher for patients in the Silzone group compared with the non-Silzone valve, but these differences were largely due to transient events because the risks of stroke were low. The Annals of Thoracic Surgery 2002 73, 785-792DOI: (10.1016/S0003-4975(01)03442-7)

Fig 5 Analysis of cumulative hazard of major paravalvular leak suggests a constant risk of 4.6% during the first 2 years after the operation. (CI = confidence interval; Postop = postoperative.) The Annals of Thoracic Surgery 2002 73, 785-792DOI: (10.1016/S0003-4975(01)03442-7)