GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice. GLP-1 and gastrin combination therapy increases.

Slides:

Advertisements

Similar presentations

Introduction Anti-CD3 monoclonal Ab has been used successfully to revert diabetes in NOD mice, a murine model for Type I diabetes. Some laboratories are.

Advertisements

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Insulin and glucagon secretion: nondiabetic and diabetic subjects.

Volume 15, Issue 1, Pages (January 2007)

Insulin content of isolated pancreas and islet morphology.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice. Improvement of insulin sensitivity by treatment of the.

Antitumor effects of FF and gemcitabine on two pancreatic PDX models.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

A–F: Xenin-25 amplifies the insulin secretory response to GIP in humans with NGT and IGT but not T2DM. A–F: Xenin-25 amplifies the insulin secretory response.

Changes (mean +SEM) in glucose, insulin, glucagon-like peptide (GLP)-1 and ghrelin from the baseline values after administration of placebo (broken lines.

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.

Glucose infusion rate required to maintain the hyperglycemic clamp during the experimental period in sedentary and exercised dogs receiving basal or elevated.

NOX-deficient NOD-Ncf1m1J immune system has a reduced capacity to transfer type 1 diabetes (T1D) to immune-deficient hosts. NOX-deficient NOD-Ncf1m1J immune.

Effect of PIs on insulin release by downstream insulin secretogogues.

α-Cells mainly express SSTR2 and SSTR3

PTx pretreatment abrogates the glucagonostatic effect of high glucose concentrations. PTx pretreatment abrogates the glucagonostatic effect of high glucose.

A: The change of plasma glucose in opioid μ-receptor knockout diabetic mice and wild-type controls receiving an oral intake of metformin (100 mg/kg). A:

Cell proliferations, ROS production, and ATP levels in HASMCs cultured under high-glucose condition. Cell proliferations, ROS production, and ATP levels.

PMPs survive STZ cytotoxicity and produce larger colonies with a higher yield of insulin+ progeny. PMPs survive STZ cytotoxicity and produce larger colonies.

Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice. Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice.

Left columns: Plasma glucose and serum insulin concentrations, circulating TF-PCA, and FVIIa activity before and during 24 h of selective hyperglycemia.

Immune cell activation detected by gene expression in representative pancreatic islets of IDDM rats after successful combination therapy with anti–TNF-α.

Fragment N expression does not affect islet morphology and cellularity

Morphometric analyses of β-cells and immune cells in IDDM rats after successful and nonsuccessful combination therapy with anti–TNF-α and anti-TCR or after.

Current insulin dose (units/kg/day) during the DCCT/EDIC study by sex (black line for females) (A), DCCT intensive vs. conventional treatment group (black.

Sustained activation of AMPK α2 in muscle of subjects with type 2 diabetes after an overnight withdrawal of metformin. Sustained activation of AMPK α2.

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

Comparison of women carrying a male fetus and those carrying a female fetus, with respect to mean adjusted blood glucose levels during the OGTT (A), mean.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Effect of berberine on white adipose tissue mass.

Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice.

Reduced β-cell mass in MCH-KO mice on normal chow and high-fat diets.

Phosphorylation of AMPK-Thr172 before and after metformin treatment in muscle from subjects with type 2 diabetes. Phosphorylation of AMPK-Thr172 before.

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

Expression of IRS2 ameliorates the effects of ATF3 in cultured β-cells

T1D is reduced in anti-CD3–treated, CXCL10-deficient RIP-LCMV-GP mice (the numbers in parentheses indicate the number of mice in each group). T1D is reduced.

GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. Beginning.

A: Chemical structure of pterosin A

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

Chop deletion preserves β-cell function in P58IPK−/− mice.

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

GLP-1 and gastrin combination therapy induces immunoregulatory cell activity in NOD mice. GLP-1 and gastrin combination therapy induces immunoregulatory.

Atrasentan reduces albuminuria in diabetic apoE KO mice.

ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.

Fig. 2 CD19 CAR T cells expressing tPSMA maintain function in vitro and in vivo. CD19 CAR T cells expressing tPSMA maintain function in vitro and in vivo.

Mean (±SE) plasma glucose concentrations before, during, and after infusions of octreotide (with growth hormone) with saline (•), with insulin replacement.

Food intake in response to central infusion of glucose (squares) or insulin (triangles) and in response to successive central infusion of insulin, insulin.

Treatment of ob/ob mice with TTR-ASOs improves insulin sensitivity.

MANF expression is required for maintaining β-cell mass.

An anti-BTC neutralizing antibody and a metalloproteinase inhibitor suppress GLP-1-induced DNA synthesis in INS(832/13) cells. [3H]thymidine incorporation.

Urinary albumin excretion and histology of glomeruli.

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

Comparison of the percentages of ducts in the pancreas containing cells showing positive staining for the different markers between control patients and.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

Effect of GSK-3 inhibitors on basal and insulin-stimulated glucose uptake in human muscle cells. Effect of GSK-3 inhibitors on basal and insulin-stimulated.

IL-1R deficiency does not protect syngeneic grafts from destruction.

Effects of GIP and GLP-1 infusion on MR-proANP levels.

Effects of vinegar (□) and placebo (⧫) on plasma glucose (A–C) and insulin (D–F) responses after a standard meal in control subjects, insulin-resistant.

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

Clinical responses to therapy from baseline to week 24 and end point with last observation carried forward (LOCF). Clinical responses to therapy from baseline.

GM-CSF is required for CA-MSC–induced tumor metastasis.

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

Presentation transcript:

GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice. GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice. Pancreata were removed from acutely diabetic NOD mice before and after 3 weeks of the treatments indicated plus an additional 5 weeks after treatments were stopped or sooner if the mice were killed because of severe diabetes as shown in Fig. 1. NOD-scid mice provide normal values for pancreatic insulin content (A) and β-cell mass (B). Values are means ± SE. *P < 0.05, **P < 0.01 vs. pretreatment values for the numbers of mice shown in parentheses. Wilma L. Suarez-Pinzon et al. Diabetes 2008;57:3281-3288 ©2008 by American Diabetes Association