Schematic representation of signaling by high-risk human papillomavirus HPV E6. Schematic representation of signaling by high-risk human papillomavirus.

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Schematic representation of signaling by high-risk human papillomavirus HPV E6. Schematic representation of signaling by high-risk human papillomavirus HPV E6. Targets for HPV E6 (99) (center column) and biological effects (right column) are shown. E6AP, E6AP ubiquitin-protein ligase (UBE3A); IRF-3, interferon-regulatory transcription factor 3; E6BP, E6 binding protein; E6TP, E6-targeted protein 1; AP-1, activator protein 1; hDig/hScrib, human homolog of Drosophila disc-large tumor suppressor/human homolog of Drosophila Scribble; p300, p300 transcriptional coactivating protein; MAML1, human homolog of Drosophila mastermind; TERT, telomerase reverse transcriptase. Martyn K. White et al. Clin. Microbiol. Rev. 2014; doi:10.1128/CMR.00124-13