Doxazosin blockade of α1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis

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Presentation transcript:

Doxazosin blockade of α1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis Susana de la Chica-Rodríguez, Pedro Cortés-Denia, María Jesús Ramírez-Expósito, Ph.D., José Manuel Arias de Saavedra, Ph.D., Rafael Sánchez-Agesta, María del Cármen Pérez, Ph.D., José Manuel Martínez-Martos, Ph.D. Fertility and Sterility Volume 88, Issue 4, Pages 1071-1075 (October 2007) DOI: 10.1016/j.fertnstert.2006.12.021 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Specific soluble and membrane-bound renin-angiotensin system (RAS)-regulating (A) AspAP, (B) GluAP and APA, (C) APN, and (D) APB activities in ovary of control and doxazosin-treated rats. Results are expressed in picomoles of their corresponding aminoacyl-ß-naphthylamide (see MATERIALS AND METHODS), hydrolyzed per minute and per milligram of protein (mean ± SEM; n = 15; ∗P<.05). de la Chica-Rodríguez. α-adrenergic receptors and RAS in steroidogenesis. Fertil Steril 2007. Fertility and Sterility 2007 88, 1071-1075DOI: (10.1016/j.fertnstert.2006.12.021) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Serum levels of (A) E2 and (B) P of control and doxazosin-treated rats. Results are expressed in picograms (of E2) or nanograms (of P) per mililiter (mean ± SEM; n = 15; ∗P<.05). de la Chica-Rodríguez. α-adrenergic receptors and RAS in steroidogenesis. Fertil Steril 2007. Fertility and Sterility 2007 88, 1071-1075DOI: (10.1016/j.fertnstert.2006.12.021) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions