The influence of SHIP2 on cell migration in breast cancer cells.

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سرطان الثدي Breast Cancer

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The influence of SHIP2 on cell migration in breast cancer cells. The influence of SHIP2 on cell migration in breast cancer cells. (A) Western blot analysis of SHIP2, PTEN and GAPDH expression in seven different breast cancer cells grown in 10% serum. (B) Cell migration velocity over three independent experiments is graphically depicted as the mean±s.e.m. for 30 individual cells quantified for each condition. The cell type is labeled on the respective graph. Cells were pre-incubated with 10 µM AS1949490 for 96 h for MDA-MB-231 and for 24 h for the other cells. The inhibitor was also present during the 15 h of live-cell migration experiment. *P<0.05; ****P<0.0001 (Student's t-test for unpaired data followed by Mann–Whitney test). Somadri Ghosh et al. J Cell Sci 2018;131:jcs216408 © 2018. Published by The Company of Biologists Ltd