Markers for Mapping by Admixture Linkage Disequilibrium in African American and Hispanic Populations Michael W. Smith, James A. Lautenberger, Hyoung.

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Markers for Mapping by Admixture Linkage Disequilibrium in African American and Hispanic Populations Michael W. Smith, James A. Lautenberger, Hyoung Doo Shin, Jean-Paul Chretien, Sadeep Shrestha, Dennis A. Gilbert, Stephen J. O’Brien The American Journal of Human Genetics Volume 69, Issue 5, Pages 1080-1094 (November 2001) DOI: 10.1086/323922 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 δc values for the loci examined across the human genome, in comparisons between European Americans and African Americans (shaded triangles) and between European Americans and Hispanics (white circles). δc values are shown on the Y-axis, and chromosome position (in centimorgans) is shown on the X-axis. The American Journal of Human Genetics 2001 69, 1080-1094DOI: (10.1086/323922) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Relationship between differences seen at individual markers in δc and LLAR (A) and STR I*(2) (B) in African Americans, along with African American versus Hispanic δc values (C). The American Journal of Human Genetics 2001 69, 1080-1094DOI: (10.1086/323922) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 3 Variograms of marker δc in African Americans. For each point, the X and Y coordinates represent the map distance between markers j and k on chromosome i (map location of j > map location of k) and half the squared difference of δc between the markers, respectively (Diggle et al. 1994). All possible pairs of markers <50 cM apart were examined, and those at intervals of ≤10 cM are shown. One observation was off the scale, with a distance of 9 cM and a difference of .25. The line is the estimated kernel smoothing function. The American Journal of Human Genetics 2001 69, 1080-1094DOI: (10.1086/323922) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 4 Cumulative frequency distributions of differences between African Americans, Asians, Hispanics, and European Americans are shown as δc (A), LLAR (B), and optimized STR allele-collapsing statistic I*(2) (C) (Kaplan et al. 1998). The American Journal of Human Genetics 2001 69, 1080-1094DOI: (10.1086/323922) Copyright © 2001 The American Society of Human Genetics Terms and Conditions