MR images of patient 2 (with juvenile-onset DRPLA).

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High-signal-intensity lesions on T2-weighted MR images
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Presentation transcript:

MR images of patient 2 (with juvenile-onset DRPLA). MR images of patient 2 (with juvenile-onset DRPLA). A–C, The T2-weighted axial images obtained at 35 years of age show marked atrophy of the pons, cerebellum, and cerebral hemispheres. High-signal-intensity lesions are observed only in the periventricular white matter at this point in time (C). D–F, On T2-weighted MR images obtained at 39 years of age, marked progression of atrophic changes is demonstrated in the cerebellum, brain stem, and cerebral hemispheres. Additionally, high-signal-intensity lesions in the cerebral white matter are clearly observed (F). Y. Sunami et al. AJNR Am J Neuroradiol 2011;32:109-114 ©2011 by American Society of Neuroradiology