Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

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Presentation transcript:

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. A: Percentage of CD86+, CD69+, or CD5+ B-cells in the spleen and in the islet infiltrate. B and C: Median fluorescence intensity (MFI) for CD19, CD40, CD24, and MHC molecules in splenic and islet-infiltrating B-cells. Dotted line in C indicates the median fluorescence intensity of negative controls. Data correspond to average values from a minimum of six mice group. Bars show the SE of the means. *Statistically significant differences between data obtained from splenic and islet-infiltrating B-cells according to Mann-Whitney U test. P < 0.02. D: CD19, CD24, H-2Ag7, and H-2Kd profiles of B-cells from islet infiltrate (thick black line) and spleen (digested [gray line] and nondigested [thin black line] with collagenase). Maria Carmen Puertas et al. Diabetes 2007;56:940-949 ©2007 by American Diabetes Association