Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis Norbert.

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Presentation transcript:

Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis Norbert Krug, MD, Abhya Gupta, MD, Philipp Badorrek, MD, Ruediger Koenen, MD, Meike Mueller, PhD, Anna Pivovarova, MSc, James Hilbert, PhD, Kristiane Wetzel, PhD, Jens M. Hohlfeld, MD, Chester Wood, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 414-419.e8 (February 2014) DOI: 10.1016/j.jaci.2013.10.013 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Adjusted means (SEs) for hourly TNSS AUC values. bid, Twice daily; qd, once daily. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Nasal eosinophil and cytokine values after 6 hours in the ECC. A, Absolute and percent nasal eosinophils count. B, Nasal IL-13 and eotaxin values. C, Nasal IL-4 and IL-5 values. bid, Twice daily; qd, once daily. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 ESC median percentage change over time. bid, Twice daily; qd, once daily. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Study design. bid, Twice daily; qd, once daily. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 CONSORT diagram illustrating the flow of patients through the study. bid, Twice daily; qd, once daily. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Gating strategy for identification of eosinophils and ESC determination. A, Dot blot showing FSC versus side scatter was used to set a region (R1) around the granulocytes excluding low FSC and side scatter events. B, The resulting histogram showing the FL2 channel was used to gate the high autofluorescent population representing the eosinophils, and a marker was set above these cells (R2). C, This cell population was displayed in a FSC/side scatter dot blot gated on R1 and R2. From this cell population, 500 to 1000 events were recorded, and the mean FSC value of this cell population in R3 representing eosinophils was determined. Journal of Allergy and Clinical Immunology 2014 133, 414-419.e8DOI: (10.1016/j.jaci.2013.10.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions