Fig. 2 Dynamics of H3K4me3 in human early development.

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Fig. 2 Dynamics of H3K4me3 in human early development. Dynamics of H3K4me3 in human early development. A, Heat maps showing H3K4me3 enrichment at the promoters marked by H3K4me3 either in both 4-cell and 8-cell embryos (n=1,272) or only in 4-cell embryos (n=1,125) (left). Maternally expressed genes were excluded. ATAC-seq (20), RNA-seq, promoter CpG density (middle) and GO analysis results (right) are also shown. B, H3K4me3, ATAC-seq, CpG density levels are shown at representative promoters (left, shaded) or distal accessible regions (right, shaded). Gene expression (left) and gamete DNA methylation (right) are also shown. C, Scatter plots comparing promoter H3K4me3 with CpG density in human oocytes, embryos and hESCs. D, Heatmaps showing enrichment of ATAC-seq and H3K4me3 around stage-specific distal ATAC-seq peaks in human early embryos. DNA methylation (28, 41, 42) and CpG density are also mapped. Weikun Xia et al. Science 2019;science.aaw5118 Copyright © 2019, American Association for the Advancement of Science