Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation Anne E. Dixon, MA, BM BCh, Richard E. Pratley,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Risk of an asthma exacerbation after bariatric surgery in adults

Fatty acids, inflammation, and asthma

Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications Elena Goleva,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Atopic dermatitis: Age and race do matter!

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Current application of exhaled nitric oxide in clinical practice

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

Mothers' anxiety during pregnancy is associated with asthma in their children Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

The National Biome Initiative: An allergy perspective

Physician needs in health informatics: Just ask the docs

Peter M. Wolfgram, MD, David B. Allen, MD

The future of allergy/immunology: Promising young investigators

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2 Phillip Lieberman, MD The Journal of Allergy.

Serum tryptase levels in atopic and nonatopic children

Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K

Reply Journal of Allergy and Clinical Immunology

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Comparison of asthma prevalence among African American teenage youth attending public high schools in rural Georgia and urban Detroit Dennis R. Ownby,

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

What is an “eosinophilic phenotype” of asthma?

Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma Sheena D. Brown, PhD, Lou Ann Brown, PhD, Susan Stephenson, PhD,

Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients Charles McSharry, PhD,

Medication use in children with asthma in Finland from 1995 to 2006

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments Waltraud Eder, MD, Walt Klimecki, PhD, Lizhi Yu, MD, Erika.

Advances in the approach to the patient with food allergy

House dust mite sublingual immunotherapy: Results of a US trial

High prevalence of severe asthma in a large random population study

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

Effect of aging on sputum inflammation and asthma control

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma Anne E. Dixon, MA, BM BCh,

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Edith Chen, PhD, Madeleine U. Shalowitz, MD, Rachel E

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Safety and efficacy of repeated monthly carboplatin desensitization

Natural history of cow’s milk allergy

The Editors’ Choice Journal of Allergy and Clinical Immunology

Susan L. Janson, DNSc, Kelly Wong McGrath, BA, Jack K

Primary prevention of asthma and allergy

Chitinases and chitinase-like proteins in TH2 inflammation and asthma

Presentation transcript:

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation Anne E. Dixon, MA, BM BCh, Richard E. Pratley, MD, Patrick M. Forgione, MD, David A. Kaminsky, MD, Laurie A. Whittaker-Leclair, MD, Laurianne A. Griffes, BA, Jayanthi Garudathri, MS, Danielle Raymond, BS, Mathew E. Poynter, PhD, Janice Y. Bunn, PhD, Charles G. Irvin, PhD Journal of Allergy and Clinical Immunology Volume 128, Issue 3, Pages 508-515.e2 (September 2011) DOI: 10.1016/j.jaci.2011.06.009 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Enrollment and follow-up of study participants. Participants were initially enrolled before bariatric surgery, although only participants who actually went through bariatric surgery were included in the analysis. There were 6 asthmatic and no control participants who did not have bariatric surgery. This was related to the fact that asthmatic patients were enrolled at presentation to the bariatric clinic, whereas control participants were only enrolled once their surgery had been scheduled. Journal of Allergy and Clinical Immunology 2011 128, 508-515.e2DOI: (10.1016/j.jaci.2011.06.009) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Change in AHR in patients with normal IgE (A) (P = .001), n = 11 and elevated IgE (B) (P = .89). Squares represent median values. A significant interaction term exists between IgE status and change in AHR (P = .01 for interaction term). Journal of Allergy and Clinical Immunology 2011 128, 508-515.e2DOI: (10.1016/j.jaci.2011.06.009) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Cytokine production from CD3-CD28–stimulated CD4+ T lymphocytes before and 12 months after bariatric surgery in control subjects (n = 15) and asthmatic patients (n = 10). P values were shown for comparison of asthmatic patients at 0 and 12 months, and there were no significant differences between asthmatic patients and control subjects at visit 0. Journal of Allergy and Clinical Immunology 2011 128, 508-515.e2DOI: (10.1016/j.jaci.2011.06.009) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions