T-CTLs are CD8+ TEMRA cells that can be expanded by IL-15 and IL-2 through selective proliferation and can be induced by LCs. T-CTLs are CD8+ TEMRA cells.

Slides:

Advertisements

Similar presentations

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Advertisements

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

Correlation between endogenous STAT5ab signaling and circulating plasma factors. Correlation between endogenous STAT5ab signaling and circulating plasma.

Expansion of Bacteroides species during colitis does not enhance TCR-specific T cell responses. Expansion of Bacteroides species during colitis does not.

Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation. Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation.

FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

Three different types of transfer functions with a codomain of [0,1].

Splenic CD169+ macrophages express a unique gene profile.

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

LV activation of DCs and subsequent CD8+ T cell priming are dependent on STING and cGAS but not on MyD88, TRIF, or MAVS. LV activation of DCs and subsequent.

FIP200 loss links to poor autophagy and high apoptosis in naïve T cells in tumor. FIP200 loss links to poor autophagy and high apoptosis in naïve T cells.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Resistance of CD141+ DCs to influenza virus in vivo in humanized mice.

Virus-specific T cell responses are detected in all MERS survivors.

Arp2/3-mediated formation of nuclear actin networks is essential for CD4+ T cell effector functions. Arp2/3-mediated formation of nuclear actin networks.

Human cells produce type I and III IFNs upon Af stimulation.

Prosthesis grasping and control.

IL-6 neutralization decreases T cell proliferation and cytokine production upon restimulation by allogeneic HUVEC. CIITA transduced HUVECs were cocultured.

DC subset cooperation for activation of antiviral T cells.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

T-bethi MP cells produce IFN-γ in response to IL-12.

Blood Tfr cells are lymphoid tissue–derived Tfr precursors.

Low accessibility to Ag for CTLs leads to low proliferation of effectors. Low accessibility to Ag for CTLs leads to low proliferation of effectors. Intravital.

Immune cell recruitment after the NIR-boosted and MN-mediated cancer immunotherapy. Immune cell recruitment after the NIR-boosted and MN-mediated cancer.

MP cells are generated from naïve cells in the periphery.

PD-1 blockade enhances T-cell function.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Prosthesis system diagram.

Variable number of CD4-CTL precursors across donors.

CD4-CTL precursor cells in the TEMRA subset.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Microrobots with different cell-carrying capacities under different grid lengths (lg) and burr lengths (lb). Microrobots with different cell-carrying capacities.

BAP1 is required for homeostatic and antigen-driven expansion of peripheral T cells. BAP1 is required for homeostatic and antigen-driven expansion of peripheral.

CD4+CLA+CD103+ T cells in skin and blood are clonally related.

CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.

Slc7a5 deficiency stimulates osteoclastogenesis in vitro.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.

Blood Tfr cells do not show specialized humoral regulatory capacity.

MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. PBMCs.

CD25 expression identifies two transcriptionally distinct subsets of very early effector cells. CD25 expression identifies two transcriptionally distinct.

Memory-biased TCRs induce weaker TCR signals than effector-biased TCRs in vitro. Memory-biased TCRs induce weaker TCR signals than effector-biased TCRs.

Loss of BAP1 blocks T cell differentiation at the DN3 stage in vitro.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Northern blot analysis of hY4 in CLL-derived exosomes and cells.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

BMS blocks functional responses in primary immune cells driven by IFNα

Potential applications of the light-induced actuator.

Simulation results of magnetic driving ability in hepatic artery, portal vein, and hepatic vein. Simulation results of magnetic driving ability in hepatic.

In vitro cell-release experiments on a glass substrate.

Human Tfr cells do not express CD25.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

Colonic Treg TCRs react to MA Helicobacter species.

Fig. 5. Vascularization of human liver seed grafts.

CD4-CTL effectors share TCR clonotypes with CD4-CTL precursors.

Treg expression of Gata3 plays a major role in controlling dermal fibrosis. Treg expression of Gata3 plays a major role in controlling dermal fibrosis.

Tregs preferentially regulate TH2 cytokines in skin.

Fig. 5 Increased myometrial cell contractility in response to fetal T cells from preterm infants. Increased myometrial cell contractility in response to.

Human basophils are unresponsive to contact-dependent or contact-independent inhibition by Tregs. Human basophils are unresponsive to contact-dependent.

Proprioception. Proprioception. (A) Computer-aided design (CAD) model of each component of the cylinder and the completed device with three different stiffness.

Blood Tfr cells are immature but are not committed in the thymus.

IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.

Comparison of MLTC responses to tumor/peptide stimuli at day 18 and day 34 of growth. Comparison of MLTC responses to tumor/peptide stimuli at day 18 and.

Meningeal γδ T cells are biased toward IL-17 production.

CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis.

Presentation transcript:

T-CTLs are CD8+ TEMRA cells that can be expanded by IL-15 and IL-2 through selective proliferation and can be induced by LCs. T-CTLs are CD8+ TEMRA cells that can be expanded by IL-15 and IL-2 through selective proliferation and can be induced by LCs. (A) PBMCs from healthy donors were treated with IL-15 (n = 13), IL-2 (n = 9), or anti-CD3 plus anti-CD28 (n = 8) for 5 days and compared with medium treatment. (B) PBMCs were labeled with CFSE and treated with medium, IL-15, or αCD3 stimulation for 5 days. Proliferation of T-CTL and M-CTL populations was compared by CFSE dilution; one representative experiment is shown above, and average proliferation is shown below (n = 3). (C) One example shows that the T-CTL compartment was examined and found to consist primarily of CCR7−, CD45RA+ (TEMRA) cells. (D) The T-CTL subset was examined for memory markers (n = 5). (E) Naïve CD8+ T cells were cocultured with allogeneic dermal CD14+ DCs or LCs isolated from human skin. CTL subset formation was interrogated after 7 days of culture. One representative experiment is shown. (F) Composite bar graph demonstrating the significantly greater ability of LCs versus DCs to induce T-CTLs (LCs, n = 9; DCs, n = 6). *P < 0.05, ***P < 0.001. Samuel J. Balin et al. Sci. Immunol. 2018;3:eaat7668 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works