Volume 66, Issue 2, Pages (August 2004)

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Volume 66, Issue 2, Pages 855-861 (August 2004) Global heterogeneity of glomerular volume distribution in early diabetic nephropathy Eiji Toyota, Yasuo Ogasawara, Katsukui Fujimoto, Tatsuya Kajita, Fumiyuki Shigeto, Takahisa Asano, Nozomi Watanabe, Fumihiko Kajiya Kidney International Volume 66, Issue 2, Pages 855-861 (August 2004) DOI: 10.1111/j.1523-1755.2004.00816.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Representative renal microvascular images observed by stereomicroscope and micro-computed tomography (micro-CT). Stereoscopic image [low magnification (A) and high magnification (B), black-white reversed images] and corresponding level of micro-CT images [low magnification (C) and high magnification (D)] in an identical LETO rat kidney were shown. In the closer view in the region of interest [white squares in (A) and (C)], the image of glomeruli (arrows) were consistent between (B and D). Bars = 1 mm (upper), and 200 μm (bottom). Kidney International 2004 66, 855-861DOI: (10.1111/j.1523-1755.2004.00816.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Representative images of three dimensional structure of individual glomerulus with higher magnification. A glomerulus of OLETF rats (A) was characterized by larger and higher irregularity, whereas similar elliptic configurations and similar size were demonstrated in LETO rats (B). Bar = 100 μm. Kidney International 2004 66, 855-861DOI: (10.1111/j.1523-1755.2004.00816.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Representative histograms of glomerular volume out of one renal sample from OLETF rat (A) and LETO rat (B). For-hundreds of glomeruli were directly calculated for each strain. Kidney International 2004 66, 855-861DOI: (10.1111/j.1523-1755.2004.00816.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Supplemental three-dimensional renal microvascular images of OLETF rat (A) and LETO rat (B) visualized by the synchrotron radiation micro-computed tomography (micro-CT). Bar = 1 mm. Kidney International 2004 66, 855-861DOI: (10.1111/j.1523-1755.2004.00816.x) Copyright © 2004 International Society of Nephrology Terms and Conditions