Figure 1. Longitudinal measures of HIV persistence and immunologic phenotype/function during anti-PD-1 therapy are ... Figure 1. Longitudinal measures.

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Figure 1. Longitudinal measures of HIV persistence and immunologic phenotype/function during anti-PD-1 therapy are ... Figure 1. Longitudinal measures of HIV persistence and immunologic phenotype/function during anti-PD-1 therapy are shown. Low-level residual plasma HIV RNA as measured by single copy assay (SCA) and CD4+ T-cell-associated HIV-1 RNA and DNA are shown in (A). Percentages of CD4+ and CD8+ T cells remained stable during therapy (B), and no consistent pattern was observed for markers of T-cell activation (dual expression of CD38 and HLA-DR; C). PD-1 expression decreased after a single dose of anti-PD1 therapy and was sustained for participants 1 and 2 throughout treatment (D). Frequencies of interferon (IFN)γ expressing CD4+ T cells (total or memory) following HIV-1 Gag peptide stimulations were low overall, with no detectable responses observed in CD8+ T cells (E). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Ann Oncol, Volume 29, Issue 10, 18 July 2018, Pages 2141–2142, https://doi.org/10.1093/annonc/mdy259 The content of this slide may be subject to copyright: please see the slide notes for details.