Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright

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Presentation transcript:

Chimeric Streptogramin-Tyrocidine Antibiotics that Overcome Streptogramin Resistance Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright Chemistry & Biology Volume 12, Issue 2, Pages 229-235 (February 2005) DOI: 10.1016/j.chembiol.2004.12.009 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Solid-Phase Chemoenzymatic and Chemical Strategies Employed in Chimeric Peptide Synthesis Chemistry & Biology 2005 12, 229-235DOI: (10.1016/j.chembiol.2004.12.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Dissection of Streptogramin-Tyrocidine Chimeric Antimicrobial Peptides Chemistry & Biology 2005 12, 229-235DOI: (10.1016/j.chembiol.2004.12.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 3 Structures of Antimicrobial Peptides Synthesized and Assayed in This Work Chemistry & Biology 2005 12, 229-235DOI: (10.1016/j.chembiol.2004.12.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 4 Impact of Antibiotics on In Vitro Translation Antibiotics were added to a final concentration of 0.1 mg/ml and the amount of [35S]-Met incorporated into in vitro translated chloramphenicol acetyltransferase quantified and normalized to the DMSO carrier control. The average of two experiments is presented. Duplicate values were within 6% of each other. Chemistry & Biology 2005 12, 229-235DOI: (10.1016/j.chembiol.2004.12.009) Copyright © 2005 Elsevier Ltd Terms and Conditions