Eosinophilia, Edema, and Nail Dystrophy: Harbingers of Severe Chronic Graft Versus Host Disease of the Skin in Children Jennifer T. Huang, MD, Leslie.

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Presentation transcript:

Eosinophilia, Edema, and Nail Dystrophy: Harbingers of Severe Chronic Graft Versus Host Disease of the Skin in Children Jennifer T. Huang, MD, Leslie Lehmann, MD, Christine Duncan, MD, Arturo Saavedra, MD, PhD, MBA Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S171-S172 (February 2014) DOI: 10.1016/j.bbmt.2013.12.278 Copyright © 2014 Terms and Conditions

Figure 1 Spectrum of morphology in sclerotic cGVHD. A: Lichen sclerosus like disease with profound dyspigmentation in patient 3. B: Myofascial disease in patient 9. C: Penile lichen sclerosus in patient 7. D. Dermal sclerotic plaques with “choke-hold” distribution in Patient 4. E and F: Bound down sclerosis of toes and guttate sclerotic papules and plaques in patient 8. Biology of Blood and Marrow Transplantation 2014 20, S171-S172DOI: (10.1016/j.bbmt.2013.12.278) Copyright © 2014 Terms and Conditions

Figure 2 Preceding edema was noted in 6 of 9 patients with sclerotic cGVHD. Clockwise from left upper: Patient 9,9,7. Biology of Blood and Marrow Transplantation 2014 20, S171-S172DOI: (10.1016/j.bbmt.2013.12.278) Copyright © 2014 Terms and Conditions

Figure 3 Ptyerygium inversum unguis in 4 participants with severe cGVHD characterized by sclerotic involvement and lung disease. Clockwise from left upper: Patient 7, 3, 4, 12. Biology of Blood and Marrow Transplantation 2014 20, S171-S172DOI: (10.1016/j.bbmt.2013.12.278) Copyright © 2014 Terms and Conditions