Running on the treadmill prolonged TrkB activation induced by exogenous BDNF in vivo. Running on the treadmill prolonged TrkB activation induced by exogenous.

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Running on the treadmill prolonged TrkB activation induced by exogenous BDNF in vivo. Running on the treadmill prolonged TrkB activation induced by exogenous BDNF in vivo. Rats were forced to run on the treadmill for 0.5 hours and rest for another 0.5 hours. BDNF was injected into the right, but not left, hippocampal CA1. Approximately 1 mg of tissue from around the injection site was dissected out at 1-hour and 4-hour time-points and was processed for the analysis of TrkB phosphorylation by western blotting. (A) Representative western blot showing the effect of running on TrkB phosphorylation induced by BDNF injection to the right hippocampus. As a control, the left hippocampus (PBS injection) was processed in the same way (right four lanes). (B) Quantification of the effect of running on TrkB phosphorylation kinetics. The values were derived from the formula shown on the right. Data are presented as the mean±s.e.m.; n = 4; *P<0.05 (paired t-test). Wei Guo et al. J Cell Sci 2014;127:2249-2260 © 2014. Published by The Company of Biologists Ltd