Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Western.

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Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Western blot analyses of dorsal hippocampus, mPFC, striatum, and cerebellum, total and SN protein extracts. Each relative value was normalized against β-actin detected on the same blot. Representative blots are shown above their respective grouped data. Left: 20 kDa pro-IGF-II and 14 kDa IGF-II; Right: IGF-IIR in BTBR and B6 mice. All data are expressed as the mean (±SEM) and normalized to the level of B6 naive mice. n = 4–8 per group. Independent t test. *p < 0.05, **p < 0.01, ***p < 0.001. For SN comparisons to total extracts for MAP2 and PSD-95 see the Extended Data (Fig. 5-1), and for detailed statistical analyses see the Extended Data table (Fig. 5-2). Adam B. Steinmetz et al. J. Neurosci. 2018;38:1015-1029 ©2018 by Society for Neuroscience