Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

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Respiration 2012;83:74–80 - DOI: /

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Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. A: Presence of transplanted Treg cells in pancreas (left) and pancreatic lymph node (right). FACS plot represents the flow cytometry performed using the organs from three mice each per group, 5 weeks postsupplementation of GFP-positive Treg cells. B: Insulitis scores at 5 weeks postsupplementation of GFP-positive Treg cells from four individual mice per group and the mean score ± SEM are plotted. C: Percentage of islets with each grade of insulitis calculated from 38 c-Rel−/− and 35 GFP-positive Treg-supplemented c-Rel−/− islets from 15 independent sections for each mouse from four mice per group (P < 0.001). D: Presence of transplanted Treg cells examined by tail vein bleeding and flow cytometry for GFP-positive cells in blood 10 weeks postsupplementation in 11 NOD and 12 NOD c-Rel−/− mice. E: c-Rel+/+ (n = 11), c-Rel−/− (n = 12), and c-Rel−/− + GFP-positive Treg (n = 12) NOD mice were analyzed for blood glucose levels as described in Fig. 5F. Significant differences by log-rank test were seen between c-Rel+/+ and c-Rel−/− mice (***P < 0.001) as well as between c-Rel+/+ and c-Rel−/− + GFP-positive Treg reconstituted mice (***P < 0.001). SSC-A, side-scatter area. Parameswaran Ramakrishnan et al. Diabetes 2016;65:2367-2379 ©2016 by American Diabetes Association