Basal synaptic transmission and climbing fiber activity remained intact in PNs of STIM1PKO mice. Basal synaptic transmission and climbing fiber activity.

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Basal synaptic transmission and climbing fiber activity remained intact in PNs of STIM1PKO mice. Basal synaptic transmission and climbing fiber activity remained intact in PNs of STIM1PKO mice. A, Miniature EPSCs. Representative trace of mEPSCs recorded from wild-type and STIM1PKO (top). Cumulative distribution plots of frequency (bottom left) and amplitude (bottom right). In both frequency and amplitude, there was no statistical significance between both groups (wild-type, n = 8; STIM1PKO, n = 11; amplitude, p = 0.206; frequency, p = 1.000). B, Miniature IPSCs. Data are presented same as in A, and there were no differences between wild-type and STIM1PKO mice (wild-type, n = 5; STIM1PKO, n = 7; amplitude, p = 0.639; frequency, p = 0.876). C, The number of CS spikelets in both groups was the same. Representative trace of CSs induced by CF stimulation from whole-cell recording (left). Average number (p = 0.884, center) and probability (right) of the spikelets were almost the same (wild-type, n = 30; STIM1PKO, n = 34). D, Properties of each spikelet showed no statistically significant differences between both groups. The peak amplitude of each spikelet was not significantly different between wild-type and STIM1PKO mice (first spike, p = 0.935; second spike, p = 0.792; third spike, p = 0.145; left). The times when each spikelet appeared (first spike, p = 0.412; second spike, p = 0.385; third spike, p = 0.494; fourth spike, p = 0.724; top, right) and the total spike duration (p = 0.968, bottom, right) were also unchanged. A Mann–Whitney U test was used for bar graphs in A and B. An independent-samples t test was used for C and D. Error bars denote the SEM. Changhyeon Ryu et al. J. Neurosci. 2017;37:8876-8894 ©2017 by Society for Neuroscience