OXT-induced analgesia in the radiant-heat paw withdrawal test (a, b) and von Frey test (c) of mechanical nociception is V1AR dependent. OXT-induced analgesia.

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From: Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII–CREB and Astroglial JAK2–STAT3 Cascades in Mice Anesthes. 2015;123(5):

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Presentation transcript:

OXT-induced analgesia in the radiant-heat paw withdrawal test (a, b) and von Frey test (c) of mechanical nociception is V1AR dependent. OXT-induced analgesia in the radiant-heat paw withdrawal test (a, b) and von Frey test (c) of mechanical nociception is V1AR dependent. Systemically administered OXT dose-dependently produces analgesia in WT and OTR KO (a), but not in V1AR KO mice (b) (n = 7–16/group). A 4 mg/kg dose of OXT produces analgesia in WT but not V1AR KO mice (c) (n = 8/group). *p < 0.05, **p < 0.01, ***p < 0.001, compared with corresponding saline group. Error bars indicate SEM. Ara Schorscher-Petcu et al. J. Neurosci. 2010;30:8274-8284 ©2010 by Society for Neuroscience